AbolerIS Pharma Presents New Data Supporting CD45RC as a Novel Therapeutic Target and Potential Biomarker in Sjögren’s Disease at EULAR 2026

Findings demonstrate strong correlation between CD45RC expression and lymphocytic infiltration in salivary glands, supporting its potential as both an early biomarker and therapeutic target in Sjögren disease

GOSSELIES, Belgium and NANTES, France, June 4, 2026 /PRNewswire/ — AbolerIS Pharma (“AbolerIS”), a clinical-stage biopharmaceutical company committed to improving the lives of people suffering from autoimmune and inflammatory diseases, today announced the presentation of new data highlighting the role of CD45RC in Sjögren’s disease (SjD) at the European Alliance of Associations for Rheumatology (EULAR) 2026 Congress, taking place in London from 3-6 June 2026.

AbolerIS is currently advancing potentially first-in-class immunomodulatory antibodies targeting CD45RC, a key regulator of antigen receptor signaling in T and B cells. Data presented at EULAR 2026 show that CD45RC is highly expressed within lymphocytic infiltrates and selectively localizes to disease-affected regions of salivary glands from patients with SjD. CD45RC expression levels strongly correlate with the degree of lymphocytic infiltration. These findings support CD45RC as both a promising therapeutic target and a novel biomarker across the full spectrum of Sjögren’s disease, including early-stage disease.

“We are pleased to present these data from our SjD study at EULAR, one of the premier global forums for rheumatology research,” said Dr. Ronald Van Brempt, CMO of AbolerIS. “These results further support CD45RC as an important regulator of pathogenic immune responses in autoimmune disease. Importantly, the ability to detect CD45RC expression in early or ‘pre-focus’ lesions suggests a unique opportunity to intervene earlier in disease progression, where treatment options remain limited. We believe that these results further support the potential of our lead antibody, ABO21009, to treat patients with SjD.” The anti-CD45RC mAb ABO21009 is currently being evaluated in a placebo- controlled, single-blind, Phase I study evaluating safety, tolerability and pharmacodynamic effects in healthy volunteers and patients with RA.

The SjD study aimed to evaluate the presence and expression of CD45RC in salivary gland tissue of patients diagnosed with SjD based on presence of anti-SSA antibodies and/or focus score (FS) (≥50 lymphocytes/4 mm2). Tissue sections from various patient and control groups were analyzed to assess SjD-associated lymphocytic infiltration and CD45RC co-expression within and adjacent to lymphocytic foci.

“What is particularly compelling is the clear relationship between CD45RC expression and the degree of lymphocytic infiltration observed in patient salivary gland biopsies,” said Prof. Dirk Elewaut, M.D., Ph.D., Ghent University Hospital and VIB Center for Inflammation Research. “These findings not only improve our understanding of disease biology in Sjögren’s disease but also highlight CD45RC as a potentially valuable biomarker for identifying and stratifying patients, including those at earlier stages of disease.”