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Bézie S., D. Meistermann, L. Boucault, S. Kilens, J. Zoppi, E. Autrusseau, A. Donnart, V. Nerrière-Daguin, F. Bellier-Waast, E. Charpentier, F. Duteille, L. David, I. Anegon* and C. Guillonneau*.

2018 | Frontiers in Immunology. 8:2014.


Although cluster of differentiation (CD)8+ regulatory T (Treg) cells have been in the last 20 years more studied since evidences of their role in tolerance as been demonstrated in transplantation, autoimmune diseases and cancer, their characteris- tics are still controversial. In this review, we will focus on recent advances on CD8+ Treg cells and description of a role for CD8+ Treg cells in tolerance in both solid organ transplantation and graft-versus-host disease and their potential for clinical trials.